{"id":12253,"date":"2022-01-26T14:48:59","date_gmt":"2022-01-26T14:48:59","guid":{"rendered":"https:\/\/direc.dk\/methodologies-for-scheduling-and-routing-droplets-in-digital-microfluidic-biochips\/"},"modified":"2025-10-20T13:11:26","modified_gmt":"2025-10-20T13:11:26","slug":"methodologies-for-scheduling-and-routing-droplets-in-digital-microfluidic-biochips","status":"publish","type":"post","link":"https:\/\/direc.dk\/da\/methodologies-for-scheduling-and-routing-droplets-in-digital-microfluidic-biochips\/","title":{"rendered":"Methodologies for scheduling and routing droplets in digital microfluidic biochips"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"12253\" class=\"elementor elementor-12253 elementor-12072\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-657151bf elementor-section-height-min-height elementor-section-items-stretch elementor-section-content-middle elementor-reverse-mobile elementor-reverse-tablet elementor-section-full_width elementor-section-height-default\" data-id=\"657151bf\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;triangle&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500.2,94.7L0,0v100h1000V0L500.2,94.7z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c1e46b6\" data-id=\"1c1e46b6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-inner-section elementor-element elementor-element-b18fe4e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b18fe4e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-61a720fd\" data-id=\"61a720fd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5269bc39 elementor-widget elementor-widget-heading\" data-id=\"5269bc39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DIREC-projekt<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41403b43 animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"41403b43\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Methodologies for scheduling and routing droplets in digital microfluidic biochips<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-308e7010\" data-id=\"308e7010\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-38e675f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"38e675f1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3672d496\" data-id=\"3672d496\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1b6a446e elementor-widget elementor-widget-heading\" data-id=\"1b6a446e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Resum\u00e9<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5d1e10fc\" data-id=\"5d1e10fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7e490ee7 elementor-widget elementor-widget-text-editor\" data-id=\"7e490ee7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Det overordnede form\u00e5l med dette projekt er at definere, unders\u00f8ge og give forel\u00f8bige metoder til planl\u00e6gning og routing af mikroliter-store v\u00e6skedr\u00e5ber p\u00e5 en plan overflade i forbindelse med digital mikrofluidik.<\/p>\n<p>Hovedideen er at anvende en holistisk tilgang i designet af planl\u00e6gnings- og routingmetoder, som tager hensyn til fysiske, topologiske og adf\u00e6rdsm\u00e6ssige begr\u00e6nsninger fra den virkelige verden. Dermed skabes l\u00f8sninger, der straks kan finde anvendelse i praktiske applikationer.<\/p>\n<p><strong>Projektleder:<\/strong> 2021-2022<\/p>\n<p><strong>Projektleder<\/strong><\/p>\n<ul>\n<li>Associate Professor Luca Pezzarossa<\/li>\n<li>Department of Applied Mathematics and Computer Science, DTU<\/li>\n<li>lpez@dtu.dk<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ed0409e elementor-widget elementor-widget-toggle\" data-id=\"1ed0409e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5161\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-5161\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Mere om projektet (p\u00e5 engelsk)<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5161\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-5161\"><h5>Value Creation<\/h5>\n<p>DMF biochips have been in the research spotlight for over a decade. However, the technology is still not ma\u0002ture at a level where it can deliver extensive automation to be used in applied biochemistry processes or for research purposes. One of the main reasons is that, although rather simple in construction, DMF biochips lack a clear automated procedure for being programmed and used. The existing methodologies for pro\u0002gramming DMF biochips require an advanced level of understanding of software programming and of the architecture of the biochip itself. These skills are not commonly found in potential target users of this tech\u0002nology, such as biologists and chemists.<\/p>\n<p>A fully automated compilation pipeline able to translate biochemical protocols expressed in a high-level rep\u0002resentation into the low-level biochip control sequences would enable access to the DMF technology by a larger number of researchers and professionals. The advanced scheduling and routing methodologies inves\u0002tigated by this project are one of the main obstacles towards broadly accessible DMF technology. This is particularly relevant for researchers and small businesses which cannot afford the large pipetting robots commonly used to automate biochemical industrial protocol. One or more DMF biochips can be pro\u0002grammed to execute ad-hoc repetitive and tedious laboratory tasks. Thus, freeing qualified working hours for more challenging laboratory tasks.<\/p>\n<p>In addition, the scheduling and routing methodologies targeted by this project enable for online decisions, such as controlling the flow of the biochemical protocols depending upon on-the-fly sensing results from the processes occurring on the biochip. This opens for a large set of possibilities in the biochemical research field. For instance, the behavior of complex biochemical protocols can be automatically adapted during exe\u0002cution using decisional constructs (if-then-else) allowing for real-time protocol optimizations and monitor\u0002ing.<\/p>\n<p>From a scientific perspective, this project would enable cross-field collaboration, develop new methodolo\u0002gies, and potentially re-purpose those techniques that are well known in one research field to solve problems of another field. For the proposed project, interesting possibilities include adapting advanced routing and<br \/>graph-related algorithms or applying well-known online algorithms techniques to manage the real-time flow control nature of the biochemical protocol. The cross-field nature of the project has the potential of provid\u0002ing a better understanding of how advanced scheduling and routing techniques can be applied in the context of a strongly constrained application such as DMF biochips. Thus, laying the ground for novel solutions, col\u0002laborations, and further research.<\/p>\n<p>Finally, it should be mentioned that the outcome of this project, or of a future larger project based on the proposed explorative research, is characterized by a concrete business value. Currently, some players have entered the market with DMF biochips built to perform a specific biochemical functionality [12,13]. A soft\u0002ware stack that includes compilation tools supporting programmability and enabling the same DMF biochip to perform different protocols largely expands the potential market of such technology. This is not the pre\u0002liminary aim of this research project, but it is indeed a long-term possibility.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-56c2e66a elementor-section-height-min-height elementor-section-items-stretch elementor-section-content-middle elementor-reverse-mobile elementor-reverse-tablet elementor-section-stretched elementor-section-boxed elementor-section-height-default\" data-id=\"56c2e66a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-251163e\" data-id=\"251163e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f2088d4 animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"5f2088d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Insights <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-3ac9fc52 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3ac9fc52\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-68702473\" data-id=\"68702473\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-687102f0 elementor-widget__width-initial elementor-widget elementor-widget-eael-post-list\" data-id=\"687102f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-post-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-post-list-container default layout-default\"><div class=\"eael-post-list-wrap\"><div class=\"eael-post-list-posts-wrap eael-post-appender eael-post-appender-687102f0\"><div class=\"eael-post-list-post \"><div class=\"eael-post-list-thumbnail \"><a href=\"https:\/\/direc.dk\/da\/et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden\/\">\n                            <img decoding=\"async\" src=\"https:\/\/direc.dk\/wp-content\/uploads\/2023\/06\/Microfluids_news-1024x576.jpg\" alt=\"\">\n                        <\/a><\/div><div class=\"eael-post-list-content\"><h2 class=\"eael-post-list-title\"><a href=\"https:\/\/direc.dk\/da\/et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden\/\" >Et samarbejde om algoritmer kan skubbe \u201dlaboratorium p\u00e5 en chip\u201d ud i den virkelige verden<\/a><\/h2><div class=\"meta\"><span class=\"eael-post-published-date\"><i class=\"far fa-calendar-alt\"><\/i> 13. juni 2023<\/span><\/div><\/div><\/div><\/div><\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-442da011\" data-id=\"442da011\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Det overordnede form\u00e5l med dette projekt er at definere, unders\u00f8ge og give forel\u00f8bige metoder til planl\u00e6gning og routing af mikroliter-store v\u00e6skedr\u00e5ber p\u00e5 en plan overflade i forbindelse med digital mikrofluidik.<\/p>\n","protected":false},"author":3,"featured_media":30479,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[188,212,33,218],"tags":[],"class_list":["post-12253","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-afsluttet-projekt","category-dataanalyse-og-algoritmer","category-explore-projekt","category-projekt"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Methodologies for scheduling and routing droplets in digital microfluidic biochips - DIREC<\/title>\n<meta name=\"description\" content=\"Artificial Intelligence brings the promise of technological means to solve problems that previously were assumed to require human intelligence, and ultimately provide human-centered solutions that are both more effective and of higher quality in a synergy 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