{"id":25056,"date":"2023-06-13T11:45:15","date_gmt":"2023-06-13T11:45:15","guid":{"rendered":"https:\/\/direc.dk\/et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden\/"},"modified":"2024-12-13T15:01:20","modified_gmt":"2024-12-13T15:01:20","slug":"et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden","status":"publish","type":"post","link":"https:\/\/direc.dk\/da\/et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden\/","title":{"rendered":"Et samarbejde om algoritmer kan skubbe \u201dlaboratorium p\u00e5 en chip\u201d ud i den virkelige verden"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tTil nyheder<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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13. juni 2023<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Et samarbejde om algoritmer kan skubbe \u201dlaboratorium p\u00e5 en chip\u201d ud i den virkelige verden<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Af S\u00f8ren Bj\u00f8rn-Hansen<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Det er sv\u00e6rt at f\u00e5 et komplekst stykke hardware til at fungere med alle variablerne i den virkelige verden. Men gennem et DIREC-projektsamarbejde kom Luca Pezzarossa meget t\u00e6ttere p\u00e5 at have en fungerende prototype.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Foto: Bax Lindhardt
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For de fleste mennesker betyder udtrykket \u201ddigital micro fluidics\u201d ikke ret meget. Men det er en teknologi, der kan revolutionere laboratoriearbejde.<\/p>\n

“Id\u00e9en er, at alt det, en biokemiker normalt bruger meget tid p\u00e5 at g\u00f8re med pipetter, kan g\u00f8res af en enkelt chip i stedet,” forklarer Luca Pezzarossa og viser en kort video af teknologien i brug.<\/p>\n

Laboratoriet p\u00e5 en chip er i bund og grund et biokemisk laboratorium skaleret ned til st\u00f8rrelsen af en lille b\u00e6rbar enhed \u2013 en mikroprocessor. Id\u00e9en er at f\u00e5 sm\u00e5 dr\u00e5ber af v\u00e6ske til at bev\u00e6ge sig rundt p\u00e5 en chip ved at aktivere en sekvens af elektroder. Luca Pezzarossa’s opgave er at f\u00e5 hardwaren og softwaren til at fungere sammen for at flytte de mikrofluidiske dr\u00e5ber p\u00e5 den rigtige m\u00e5de.<\/p>\n

“Men \u00e9n ting, der er meget almindelig inden for dette felt, er, at de personer, der laver denne forskning, ikke er biokemikere,” siger han.
\nProblemet med det er, at der er begr\u00e6nsninger i den virkelige verden, der g\u00f8r det meget sv\u00e6rere at flytte dr\u00e5berne.<\/p>\n

“To dr\u00e5ber m\u00e5 ikke komme s\u00e5 t\u00e6t p\u00e5 hinanden, som de g\u00f8r i en simulering, fordi de s\u00e5 ville r\u00f8re hinanden og flyde sammen. Rent biologisk kan nogle dr\u00e5ber ogs\u00e5 efterlade en forurenende rest. Bloddr\u00e5ber tr\u00e6kker et spor for eksempel, og s\u00e5 kan andre dr\u00e5ber ikke bev\u00e6ge sig derhen, hvor blodet har v\u00e6ret f\u00f8r,” forklarer Luca Pezzarossa.<\/p>\n

Det eksempel repr\u00e6senterer et vanskeligt problem. At overs\u00e6tte noget fra en brugervenlig h\u00f8jniveau-protokol – noget, der er nyttigt for en biokemiker – til en styresekvens er meget sv\u00e6rt. Is\u00e6r n\u00e5r begr\u00e6nsningerne er komplekse virkelighedsbaserede problemer, som f.eks. en dr\u00e5be, der efterlader en forurenende blodsti p\u00e5 chippen.<\/p>\n

“Da jeg pr\u00e6senterede disse udfordringer p\u00e5 et DIREC-seminar, sagde to algoritmeorienterede forskere: ‘Det her er meget sp\u00e6ndende fra et teoretisk synspunkt. Vi b\u00f8r ans\u00f8ge om et DIREC Explore-projekt.’ Og det gjorde vi s\u00e5,” siger Luca Pezzarossa.<\/p>\n

Digital Research Centre Denmark (DIREC) st\u00f8tter tv\u00e6rfaglig forskning – ofte med eksterne partnere – med s\u00e5kaldte Explore-projekter, der er sm\u00e5 agile forskningsprojekter med det form\u00e5l at unders\u00f8ge nye ideer.<\/p>\n

I st\u00f8rstedelen af 2022 arbejdede han sammen med to andre lektorer, Eva Rotenberg fra DTU Compute og Lene Monrad Favrholdt fra Syddansk Universitet, p\u00e5 at udvikle algoritmer, der kunne styre denne tidsplanl\u00e6gning og ruteplanl\u00e6gning p\u00e5 anvendte cyber-fysiske systemer – mens DTU-forskningsassistent Kasper Skov Johansen, der nu er ph.d.-studerende ved DTU, stod for det meste af det praktiske arbejde.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Foto: Bax Lindhardt
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\n\t\t\t\t\t\t\t\t\t“Vi endte med at opbygge et matematisk framework til at beskrive begr\u00e6nsningerne. Hvad er de forskellige gr\u00e6nser og regler, som disse dr\u00e5ber skal overholde?” forklarer han.\r\n\r\nDe har fremlagt ideerne og ved, hvor de vil f\u00f8re projektet hen n\u00e6ste gang. Nu leder de bare efter finansiering. P\u00e5 lang sigt er deres m\u00e5l at forbedre laboratoriet p\u00e5 en chip, s\u00e5 det fungerer godt i den virkelige verden i stedet for i en simulering.\r\n\r\nLuca Pezzarossa tror, at en prototype er et par \u00e5r v\u00e6k. Men det afh\u00e6nger alt sammen af, hvordan brugerne af laboratoriet p\u00e5 en chip reagerer.\r\n\r\n“N\u00e5r folk begynder at bruge noget, vil de sige ‘det burde ikke opf\u00f8re sig s\u00e5dan’. Men det er netop pointen. At fors\u00f8ge at g\u00f8re noget nyttigt og ikke bare flytte farvede dr\u00e5ber rundt. Nogle problemer opdager man kun, n\u00e5r man bringer tingene ud i den virkelige verden,” siger han.\r\n\r\nGennem deres samarbejde opdagede teamet, at det var meget mere komplekst at udvikle de rigtige algoritmer, end de troede. De lykkedes kun delvist med at skabe de rigtige algoritmer. Og det er okay, synes Luca Pezzarossa:\r\n\r\n“Det er et sv\u00e6rt problem at l\u00f8se. Og det er ogs\u00e5 form\u00e5let med DIREC Explore. Du udforsker en id\u00e9 og ser, om der er mere, du kan g\u00f8re. Og i dette tilf\u00e6lde var der mere. Derfor leder vi efter mere finansiering.”\r\n\r\nIf\u00f8lge Luca Pezzarossa var DIREC Explore-projektet afg\u00f8rende, fordi det fik dem til at t\u00e6nke anderledes.\r\n\r\n“Vi fors\u00f8gte at bringe to verdener sammen, der er meget forskellige. Jeg kommer fra den integrerede systemverden, der er meget st\u00f8jende og virkelig. Vi bygger ting indeni raketter og biler. Men algoritmeverdenen er meget formel og abstrakt p\u00e5 samme tid. Og det, tror jeg, var et af m\u00e5lene med explore-projektet, at bringe folk sammen fra forskellige felter,” siger han og forts\u00e6tter:\r\n\r\n“Jeg l\u00e6rte meget om kommunikation og behovet for at forklare ting p\u00e5 et f\u00e6lles sprog. Det er nogle gange sv\u00e6rt, men det er det hele v\u00e6rd. Ellers er du i din perfekte kasse med alle de ting, du ved. Og det er ogs\u00e5 god forskning, i princippet. Men den virkelige verden er ikke lavet af perfekte kasser.”\r\n\r\nLuca Pezzarossa er adjunkt p\u00e5 DTU Compute. Han kom f\u00f8rst til DTU fra sit hjemland Italien som en del af et Erasmus-udvekslingsprogram i 2012. Han skrev sin kandidatafhandling p\u00e5 DTU to \u00e5r senere og har v\u00e6ret her siden da.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

13. juni 2023<\/b>
\nDet er sv\u00e6rt at f\u00e5 et komplekst stykke hardware til at fungere med alle variablerne i den virkelige verden. Men gennem et DIREC-projektsamarbejde kom Luca Pezzarossa meget t\u00e6ttere p\u00e5 at have en fungerende prototype.<\/p>\n","protected":false},"author":3,"featured_media":25045,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179,31],"tags":[89,147],"class_list":["post-25056","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-future-of-work-da","category-nyheder","tag-impact-story-da","tag-p27-da"],"yoast_head":"\nEt samarbejde om algoritmer kan skubbe \u201dlaboratorium p\u00e5 en chip\u201d ud i den virkelige verden - DIREC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/direc.dk\/da\/et-samarbejde-om-algoritmer-kan-skubbe-laboratorium-paa-en-chip-ud-i-den-virkelige-verden\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Et samarbejde om algoritmer kan skubbe \u201dlaboratorium p\u00e5 en chip\u201d ud i den virkelige verden - DIREC\" \/>\n<meta property=\"og:description\" content=\"13. juni 2023 Det er sv\u00e6rt at f\u00e5 et komplekst stykke hardware til at fungere med alle variablerne i den virkelige verden. 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